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Today is the biggest day in the super-organized life of uptight overachiever Jane Ryan (Ashley Olsen). She's due to give a major speech at Columbia University for a competition to win a prestigious scholarship to Oxford University. Meanwhile, her rebellious sister Roxy (Mary-Kate Olsen) is planning to ditch school and go backstage at a Simple Plan music video shoot in Manhattan, where she'll slip her demo tape to the band's A & R team. Despite having so little in common and so much emotional distance between them, the adversarial sisters reluctantly journey together to the Big Apple, but their plans go wildly awry when a mix-up involving Jane's all-important dayplanner lands them in the middle of a shady black market music piracy scheme. Sidetracked, sideswiped and hotly pursued from Chinatown to Harlem by whacked-out truancy officer (Eugene Levy) and a wannabe gangster (Andy Richter), Jane and Roxy reluctantly join forces and find unexpected romance with a charming Senator's son (Jared Padalecki) and a handsome bike messenger (Riley Smith). If Jane doesn't recover her dayplanner – and the crucial speech inside it – she can kiss her college scholarship goodbye. If Lomax finally catches up with Roxy, she'll be drummed out of high school for good. Roxy and Jane seem to have everything going against them…but anything can change in a "New York Minute"!
Story centers on Marco Polo, a Venice merchant, who served as an ambassador to the empire of Kublai Khan as he traveled with his father and uncle through a war-torn Asia.
In the early 1990s, a Johnson & Johnson pharmaceutical rep helps sell the anti-anemia drug Procrit until he comes to believe it is causing harm. The salesman, who works in Johnson & Johnson's new biotech division, is fired from the pharmaceutical company after warning that the drug he had championed is dangerous. Attorney Jan Schlichtmann takes on the case for the sales rep and the plaintiffs.