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The escalating events begin when African-born U.N. translator Silvia Broome (Kidman) alleges that she has overheard a death threat against an African head of state, spoken in a rare dialect few people other than Silvia can understand. With the words "The Teacher will never leave this room alive," in an instant, Silvia's life is turned upside down as she becomes a hunted target of the killers. Placed under the protection of federal agent Tobin Keller (Penn), Silvia's world only grows more nightmarish. As Keller digs deeper into his eyewitness' past and her secretive world of global connections, the more suspicious he becomes that she herself might be involved in the conspiracy. With every step of the way, he finds more reasons to mistrust her.
Sharp-witted Terry Wolfmeyer, a suburban wife and mother, has her life take an unusual turn when her husband unexpectedly disappears. Struggling to deal with his sudden absence, Terry finds herself increasingly at odds with her four headstrong daughters and regularly drowning her anger in alcohol, until she develops an offbeat relationship with her next-door neighbor, Denny. A once-great baseball star turned radio DJ, Denny becomes a drinking buddy for Terry and slowly evolves into her source of strength, as well as an ad-hoc father to her daughters. But things get complicated as Terry's daughters grow accustomed to having Denny around while attempting to juggle not only their mother's romantic dilemmas, but their own.
When a British diplomat's wife—a socially-conscious lawyer—turns up dead in Kenya, he sets out to find the truth surrounding her murder. In the process, he finds out that his wife had been compiling data against a multinational drug company that uses helpless Africans as guinea pigs to test a tuberculosis remedy with unfortunately fatal side effects. Therefore those who may have had the most reason to silence her are closer to home than he ever imagined.
Flipping back and forth between the 18th Century and the hapless efforts of the 21st Century filmakers, "A Cock and Bull Story" is the making of a movie adapted from the notoriously unfilmable English literature masterpiece, "The Life and Opinions of Tristram Sahndy, Gentlemen," written by Laurence Sterne.
The story begins with Tristram Shandy (Steve Coogan) narrating his life story as he sees it. Crammed with literary jokes and dark humor, Shandy's warped childhood tales are constantly interrupted by his family and household, inadvertently revealing far more about himself than any conventional autobiography.
At the dramatic moment of Tristram's birth, the 1st Assistant Director calls cut, marking the end of a filming day on the set of Tristram Shandy. We then see Steve Coogan, the other actors and crew through the course of a chaotic evening on set. Steve Coogan's wife arrives with their six month old baby, a journalist is chasing him about a scandalous story, his agent has arrived with a load of Hollywood scripts and the film financiers are threatening to pull the plug.