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Donnie is a troubled high school student: in therapy, prone to sleepwalking and in possession of an imaginary friend, a six-foot rabbit named Frank, who tells him the world is going to end in 28 days, 6 hours, 42 minutes and 12 seconds. During that time he will navigate teenage life, narrowly avoid death in the form of a falling jet engine, follow Frank's maladjusted instructions and try to maintain the space-time continuum.
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A young medical prodigy is pushed to the mental, physical and emotional brink over the course of one night, after joining an elite team of doctors that treat the rarest, most gruesome and dangerous illnesses on Earth.