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The film is set in 1965, the year Sedgwick met Andy Warhol and became known as his muse and later died of a barbiturate overdose in 1971 at the age of 28.
The story centers on an opera singer (Brittany Murphy) who seeks out the services of Sigmund Freud in post-World War I Vienna. Haunted by hallucinatory dreams about a white hotel, she becomes Freud's famous case study Anna G. Together, they unlock the key to figuring out her memories and her premonitions of the future, which include the Holocaust.