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Set in 1983, divorcée Ruth Coker Burks lives a busy life. She is devoted to her work, her six-year-old daughter Jessica, and is a devout Christian. When a handsome new neighbor turns out to be a gay New-Yorker who has fled the City and returned home after the death of his partner to AIDS, she decides to educate herself on the epidemic sweeping the country. Ruth becomes a champion and caregiver for AIDS sufferers in 1980s America.