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When the disappearance of a young girl grips the city of Baltimore on Thanksgiving 1966, the lives of two women converge on a fatal collision course. Maddie Schwartz (Natalie Portman) is a Jewish housewife seeking to shed a secret past and reinvent herself as an investigative journalist, and Cleo Johnson (Moses Ingram) is a mother navigating the political underbelly of Black Baltimore while struggling to provide for her family. Their disparate lives seem parallel at first, but when Maddie becomes fixated on Cleo’s mystifying death, a chasm opens that puts everyone around them in danger.