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The story follows Jerry (Cuba Gooding, Jr.), a jilted guy left by his fiancee (Vivica A. Fox), deciding a vacation is in order after his best friend Nick (Horatio Sanz) sells him on the idea of a singles cruise packed with available gorgeous women. However, once out to sea, Jerry and Nick quickly realize they've mistakenly ended up on a cruise of a different kind.
Uma Thurman's character, a pregnant assassin named the Bride, is shot by her boss, Bill, and her co-workers at her wedding (the wedding guests are also shot). She survives, though, waking up exceedingly angry after a five-year coma, and decides to hunt down and kill every single one of the assassins who were responsible, saving Bill for last.