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Based on the MTV animated series by Peter Chung, "Aeon Flux" is set 400 years in the future, when disease has wiped out the majority of the earth's population except for one walled, protected city-state, Bregna, ruled by a congress of scientists. The story centers on Aeon Flux (Charlize Theron), the top operative in the underground ‘Monican' rebellion – led by The Handler (Frances McDormand). When Aeon is sent on a mission to kill a government leader, she uncovers a world of secrets.
Stella Raphael, a cultured and elegant but restless young woman, lives with her husband, Max, a forensic psychiatrist, and their small son, Charlie, at a high-security mental hospital in rural England. Isolated from the urban excitement she craves, Stella is unhappy with her husband and her life, and when she comes into contact with the brilliant and attractive sculptor Edgar Stark, a patient who is engaged in rebuilding the asylum's decrepit Victorian conservatory, she begins to fall in love. Her discovery that Edgar was confined to the hospital after he brutally murdered and disfigured his wife in a psychotic, jealous rage fails to deter Stella from her growing passion, and eventually her love for Edgar is pitted against her husband, her child, the institution, and the entire fabric of her society. Finally Stella makes her choice, precipitating an appalling tragedy and changing the course of several lives.