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When Andrew Largeman (Zach Braff) returns to his hometown in New Jersey for the first time in 10 years to attend his mother's funeral, he is reconnected with the world he left behind, and meets a girl, Samantha (Natalie Portman), who may change his life forever. Having recently stopped taking the powerful antidepressants he had been prescribed for years, Largeman's journey of self-discovery prompted by his return causes him to have a more healthy rediscovery of himself, which includes confronting his psychologist father (Ian Holm) and helping Samantha through her own psychological issues.