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When a British diplomat's wife—a socially-conscious lawyer—turns up dead in Kenya, he sets out to find the truth surrounding her murder. In the process, he finds out that his wife had been compiling data against a multinational drug company that uses helpless Africans as guinea pigs to test a tuberculosis remedy with unfortunately fatal side effects. Therefore those who may have had the most reason to silence her are closer to home than he ever imagined.
Florentino (Bardem), rejected by the beautiful Fermina (Mezzogiorno) at a young age, devotes much of his adult life to carnal affairs as a desperate attempt to heal his broken heart.