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It is a moonlit night in Los Angeles, when something lurking in the shadows causes their car to suddenly swerve off the road, a teenaged brother and his career-driven sister emerge relatively unscathed, but forever changed by the accident. Suddenly, the siblings find themselves blessed with increased physical strength, heightened sensibilities and undeniable allure to everyone around them. But, what if what happened to them that night wasn't just an accident and what seemed like fate was really something more? It is only a matter of time before Ellie (Christina Ricci) and Jimmy (Jesse Eisenberg) can no longer control these impulses because their newfound power comes with a price that they never expected to pay and a mystery that only they can solve.
John Clark is a man with a wonderful job, a charming wife and a loving family, who nevertheless feels that something is missing as he makes his way every day through the city. Each evening on his commute home, John sees a beautiful woman, staring with a lost expression through the window of a dance studio. Haunted by her gaze, John impulsively jumps off the train one night, and sings up for dance lessons, hoping to meet her. At first, it seems like a mistake. His teacher turns out to be not Paulina, but the older Miss Mitzi, and John proves just as clumsy as his equally clueless classmates on the dance-floor. Even worse, when he does not meet Paulina, she icily tells John she hopes he has come to the studio to seriously study dance and not to look for a date. But, as his lessons continue, John falls in love with dancing. Keeping his new obsession fro his family and co-workers, John feverishly trains for Chicago's biggest dance competition. His friendship with Paulina blossoms, as his enthusiasm rekindles her own lost passion for dance. But the more time John spends away from home, the more his wife becomes suspicious. With his secret about to be revealed, John will have to do some fancy footwork to keep his dream going and realize what it is he really yearns for.