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Lazy stoner Dale Denton (Seth Rogen) has only one reason to visit his equally lazy dealer Saul Silver (James Franco): to purchase weed, specifically, a rare new strain called Pineapple Express. But when Dale becomes the only witness to a murder by a crooked cop (Rosie Perez) and the city's most dangerous drug lord (Gary Cole), he panics and dumps his roach of Pineapple Express at the scene. Dale now has another reason to visit Saul: to find out if the weed is so rare that it can be traced back to him. And it is. As Dale and Saul run for their lives, they quickly discover that they're not suffering from weed-fueled paranoia; incredibly, the bad guys really are hot on their trail and trying to figure out the fastest way to kill them both. All aboard "The Pineapple Express".
Eighteen-year-old Matthew Kidman (Emile Hirsch) is a straight-arrow over-achiever who has never really lived life, until he falls for his new neighbor, the beautiful and seemingly innocent Danielle (Elisha Cuthbert). When Matthew discovers this perfect "girl next door" is a one-time porn star, his sheltered existence begins to spin out of control. Ultimately, Danielle helps Matthew emerge from his shell and discover that sometimes you have to risk everything for the person you love - as he helps her rediscover her innocence.
After the pharmacy in her small town is robbed, June (Esther Povitsky), who still lives at home with her parents (Beverly D’Angelo and James Remar) takes matters into her own hands to solve the crime, while at the same time trying to get over her ex-boyfriend (Haley Joel Osment) and become more of an adult.
Set in the competitive world of New York City real estate, a couple (Drew Barrymore and Ben Stiller), whose dream home is a converted duplex apartment in the perfect neighborhood, decide to kill the sweet little old lady (Eileen Essell) who's currently living there, or else they'll never get to buy it...