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In "Twisted", a police detective named Jessica Shepard (Ashley Judd) tracks a serial killer who murders the men she dates. When Jessica begins blacking out before each murder takes place, her partner, Mike Delmarco (Andy Garcia), and the police commissioner (Samuel L. Jackson) target her as the prime suspect.
The story centers on Charlie (Quinn), a Los Angeles billionaire financial whiz who goes into self-imposed exile in Tijuana after his empire is revealed to have been a Ponzi scheme. While looking for the woman he abandoned there 25 years before, Charlie is pursued by a Mexican gangster (Andy Garcia), a federal agent (Mario Van Peebles) and thugs sent by a former client (Luke Goss) looking to retrieve his money.