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Based on the MTV animated series by Peter Chung, "Aeon Flux" is set 400 years in the future, when disease has wiped out the majority of the earth's population except for one walled, protected city-state, Bregna, ruled by a congress of scientists. The story centers on Aeon Flux (Charlize Theron), the top operative in the underground ‘Monican' rebellion – led by The Handler (Frances McDormand). When Aeon is sent on a mission to kill a government leader, she uncovers a world of secrets.
Set in present day, the story follows the adventures of "good old boy" cousins, Bo (Seann William Scott) and Luke (Johnny Knoxville) Duke, who with the help of their eye-catching cousin Daisy (Jessica Simpson) and moonshine running Uncle Jesse (Willie Nelson), try and save the family farm from being destroyed by Hazzard County's corrupt commissioner Boss Hogg (Burt Reynolds). Their efforts constantly find the "Duke Boys" eluding authorities in "The General Lee," their famed 1969 orange Dodge Charger that keeps them one step ahead of the dimwitted antics of the small southern town's Sheriff Roscoe P. Coltrane (M.C. Gainey).
Just when his career hits an all-time low, a conceited and frustrated movie star, Jack Wyatt, gets one last shot when he's cast to do a remake of a cult TV series, Bewitched, playing the lead role of 'Darren'. In search of his leading lady, 'Samantha', the competitive, insecure Wyatt makes it pretty clear to his producers that his co-star needs to be an unknown, so as not to steal his thunder. Finally, after weeks of searching, he finds the perfect witch in the shy Isabel Bigelow, but he has no idea just how 'perfect' she really is. So, as the script for the popular show is being re-tooled to, instead, center around Darren's character, the actor Wyatt soon discovers that his increasingly annoyed new leading lady, Isabel—who begins to wreak havoc on set—is an actual witch, who can truly cast spells.