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Based on the life of drug-kingpin-turned-informant, Frank Lucas, who grew up in segregated North Carolina where he watched as his cousin was shot by the Klan for looking at a white girl. He eventually made his way to Harlem where he became a heroin kingpin by traveling to Asia's Golden Triangle to make connections, shipping heroin back to the US in the coffins of soldiers killed in Vietnam. He soon made upwards of one million dollars a day in drug sales. Lucas was shadowed by lawman, Richie Roberts, who finally helped bring the kingpin to justice. The two then worked together to expose the crooked cops and foreign nationals who made importing heroin so easy.
On the afternoon of July 1, 1981, Los Angeles police responded to a distress call at 8763 Wonderland Avenue and soon discovered a grisly quadruple homicide, later compared to the gruesome slaughter at the Tate household at the hands of the Charles Manson family 10 years earlier. Ron Launius (Josh Lucas), Billy Deverell (Tim Blake Nelson), Barbara Richardson (Natasha Gregson Wagner) and Joy Miller (Janeane Garofalo) were brutally murdered, and Ron's wife Susan (Christina Applegate) was left in critical condition. The police investigation that followed - led by detectives Sam Nico (Ted Levine), Louis Cruz (Frankie G.) and Mike Peters (M.C. Gainey) - would unearth a seedy world of drugs and violence, ultimately revealing a motley crew from LA's underbelly including ex-con David Lind (Dylan McDermott), nightclub impresario Eddie Nash (Eric Bogosian), the most unlikely of American heroes - porn legend John Holmes (Val Kilmer) - Holmes' estranged wife Sharon (Lisa Kudrow) and his teenage lover Dawn Schiller (Kate Bosworth).