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John C. Reilly ("Chicago"), Diego Luna ("Y Tu Mama Tambien") and Maggie Gyllenhaal ("Secretary") star in a contemporary caper movie set in Los Angeles. It's the story of an extremely odd couple: a young Latino man who will do anything for his family (Luna) and a 30-something scheming white guy who will do anything to his family (Reilly). One wants to save his father. The other wants to get rich, in any way possible. So when they come across one of the most valuable pieces of currency in U.S. history, they're suddenly stuck together, and that's just . . . criminal. All they have to do is sell it, which is where the real problems begin. And of course the only way out is family: the one person who can help them, hates them: the schemer's sister (Gyllenhaal).
Trevor Reznik, a machinist, has lost the ability to sleep. But this is no ordinary insomnia. Trevor has not slept in a year. Fatigue has led to a shocking deterioration of his physical and mental health. Suspicious of his appearance, Trevor's co-workers first shy away from him, then turn against him after he's involved in a shop accident that costs a man his arm. They blame Trevor for the accident. He has become a liability to himself and others, and now they want him out. Plagued with guilt, Trevor's shame becomes suspicion, then paranoia, when it appears his workmates are conspiring to have him fired –- or worse. First he finds cryptic notes left in his apartment. Next he's told that a mysterious co-worker involved in the accident doesn't exist. Are these mysteries part of a plot to drive Trevor mad? Or is it fatigue that's robbing him of his reason? Determined to find an answer, Trevor investigates the strange occurrences that are turning his world into a sleepless nightmare. Yet the more he learns, the less he wants to know.