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It is a moonlit night in Los Angeles, when something lurking in the shadows causes their car to suddenly swerve off the road, a teenaged brother and his career-driven sister emerge relatively unscathed, but forever changed by the accident. Suddenly, the siblings find themselves blessed with increased physical strength, heightened sensibilities and undeniable allure to everyone around them. But, what if what happened to them that night wasn't just an accident and what seemed like fate was really something more? It is only a matter of time before Ellie (Christina Ricci) and Jimmy (Jesse Eisenberg) can no longer control these impulses because their newfound power comes with a price that they never expected to pay and a mystery that only they can solve.
Set in London, this is the story of Dr. Adrian Strother (Goran Visnjic), an American insomniac hypnotherapist with telepathic powers, who gets caught up in the pursuit of a ritualistic serial killer, when Scotland Yard enlists his help in talking to a young mute girl who escaped.