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In "Doomsday", a lethal virus spreads throughout a major country and kills hundreds of thousands. To contain the newly identified Reaper, the authorities brutally quarantine the country as it succumbs to fear and chaos. The literal walling-off works for three decades – until Reaper violently resurfaces in a major city. An elite group of specialists, including Eden Sinclair (Mitra), is urgently dispatched into the still-quarantined country to retrieve a cure by any means necessary. Shut off from the rest of the world, the unit must battle through a landscape that has become a waking nightmare.
Elmo McElroy (Samuel L. Jackson), a streetwise American master chemist, heads to England to set up his last big deal - to introduce a new designer drug to the European market. McElroy soon becomes embroiled in a web of double-dealing as he's escorted around Liverpool's underworld and rave scene by rabid local hood Felix De Souza (Robert Carlyle) who hates all things American.