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It is a moonlit night in Los Angeles, when something lurking in the shadows causes their car to suddenly swerve off the road, a teenaged brother and his career-driven sister emerge relatively unscathed, but forever changed by the accident. Suddenly, the siblings find themselves blessed with increased physical strength, heightened sensibilities and undeniable allure to everyone around them. But, what if what happened to them that night wasn't just an accident and what seemed like fate was really something more? It is only a matter of time before Ellie (Christina Ricci) and Jimmy (Jesse Eisenberg) can no longer control these impulses because their newfound power comes with a price that they never expected to pay and a mystery that only they can solve.
In a night pregnant with a strange mix of tension and dizzy abandon, lovers Carla and Martin prowl clubs before drunkenly wandering back to his car. While he comes across as crass nouveau riche, she appears more liberal. Their conspicuous affluence, however, makes them ideal targets for kidnappers, and the trio of Trece, Budu and Niga gets a bead on them and promptly sweeps them up at gunpoint. The kidnappers then demand $20,000 to be delivered in two hours. Carla phones her rich father Sergio to procure the money, but chaos soon ensues. A botched ATM robbery is followed by a stopover at the palatial estate of a gay drug dealer.