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Follows a group of New Yorkers on a late-night ferry ride that turns deadly when a mischievous mouse begins a rampage, targeting unsuspecting passengers. The unlikely crew must band together to thwart the murderous menace before their relaxing commute turns into a nightmare.
When Roy and Elaine Keenan realize their family is drifting apart, they decide that something needs to be done. Roy forces his work to take a back seat and they seize the opportunity to recreate a vacation from their past. A peaceful stay in a quaint hotel is just what they need, however that is not what is in store for them. With four deranged murderers patrolling the seemingly mundane halls, the odds are definitely not in the Keenan family's favor. Roy must fight for his life and those of his family as their simple weekend getaway truly turns into a vacation to die for.