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Berlin, the future, but close enough to feel familiar: In this loud, often brutal city, Leo (Alexander Skarsgård) - unable to speak from a childhood accident - searches for his missing girlfriend, the love of his life, his salvation, through dark streets, frenzied plazas, and the full spectrum of the cities shadow-dwellers. As he seeks answers, Leo finds himself mixed up with Cactus Bill (Paul Rudd) and Duck (Justin Theroux), a pair of irreverent US army surgeons on a mission all their own.