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A former national security expert investigates the death of his sister and her young son. Clues lead him to a clinic in the mountains of Italy, where a terrifying secret experiment is being conducted.
The Lodger follows a grizzled detective Chandler Manning (Alfred Molina) on the trail of a ruthless killer intent on slaughtering prostitutes along West Hollywood's Sunset Strip. Meanwhile, a mysterious stranger called Malcolm Slaight (Simon Baker) rents a guesthouse from Joe (Donal Logue) and Ellen Bunting (Hope Davis), a married couple struggling to preserve their fragile union after their plans to start a family have ended in tragedy.
Story centers on a man standing on a high-rise ledge who insists he must jump by noon as the policeman below (Terrence Howard) tries to manage the situation.
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