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Earlier tonight, a bizarre disease was unleashed in a run-down Los Angeles tenement... and no one got out alive. Yet something escaped. Now, aboard Flight 318, the first symptoms begin to show. As the infection begins to takes root, innocent passengers suddenly transform into terrifying, bloodthirsty killers. Forced to land at an isolated terminal, and surrounded by armed government agents, the crew and passengers grow increasingly desperate. The only question now is how far they will go to survive.
Television reporter Angela Vidal (Jennifer Carpenter) and her cameraman (Steve Harris) are assigned to spend the night shift with a Los Angeles Fire Station. After a routine 911 call takes them to a small apartment building, they find police officers already on the scene in response to blood curdling screams coming from one of the apartment units. They soon learn that a woman living in the building has been infected by something unknown. After a few of the residents are viciously attacked, they try to escape with the news crew in tow, only to find that the CDC has quarantined the building. Phones, internet, televisions and cell phone access have been cut-off, and officials are not relaying information to those locked inside. When the quarantine is finally lifted, the only evidence of what took place is the news crew's videotape.