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Based on Augusten Burroughs' best-selling memoir, the story follows Deirdre Burroughs (Annette Bening), a 1970s poet with bipolar disorder. Her instability after a messy divorce leads her to send her 12-year-old son to live with an unusual psychiatrist and his eccentric family.
New York City homicide detective Vincent LaMarca has forged a long and distinguished career in law enforcement, making a name for himself as a man intensely committed to his work. But on his latest case, the stakes are higher for Vincent - the suspect he's investigating is his own son, Joey. Vincent and Joey have been painfully estranged ever since Vincent divorced Joey's mother and left the decaying boardwalks of Long Beach, Long Island for the anonymity of Manhattan and a successful career with the NYPD. He lives his life in solitude, keeping his girlfriend at arm's length; the closest relationship he maintains is with his partner, Reg - and Vincent makes sure that friendship stops at the precinct door. As long as Vincent lives in the protection of the present, he doesn't have to deal with the pain of his past - or his sorrow over his broken relationship with Joey. But this murder investigation is drawing Vincent home to Long Beach, the self-proclaimed "City by the Sea," where the past has been waiting for him to return. The agonizing memory that has tortured him all his life - the death of his father, a convicted murderer who was executed when Vincent was just a boy - still plagues him. In the course of the investigation, he discovers that his own unresolved pain and failures as a father have deeply influenced Joey's life, and the destructive choices he has made. As a cop, Vincent must bring a criminal to justice; as a father he must find a way to save his son. Now he will put his life on the line in order to do right by both his family and his profession.
A young academic tries to formulate a series of mathematical equations that will force his randy girlfriend to make a commitment to him.