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Sixteen years ago while being pursued by the law and high on drugs, Joe (Billy Bob Thornton) was responsible for a car accident that killed his young son and seriously injured his wife, Chrystal (Lisa Blount), breaking her neck. Returning to his hometown in the Ozarks of Arkansas after his time in prison for the accident, Joe is faced with the challenge of finally coming to terms with Chrystal, who is still plagued with pain, both physical and psychological.
Set in London, this is the story of Dr. Adrian Strother (Goran Visnjic), an American insomniac hypnotherapist with telepathic powers, who gets caught up in the pursuit of a ritualistic serial killer, when Scotland Yard enlists his help in talking to a young mute girl who escaped.