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Ray Keene (Cusack), a father who wants to redeem himself in the eyes of his son, is trying to bring Cordell (Freeman), a world-class assassin to justice. All the while, he must protect his son and evade the assassin's team who are methodically hunting them down in the wilderness.
Set in London, this is the story of Dr. Adrian Strother (Goran Visnjic), an American insomniac hypnotherapist with telepathic powers, who gets caught up in the pursuit of a ritualistic serial killer, when Scotland Yard enlists his help in talking to a young mute girl who escaped.
Inspired by "Cujo" and "The Birds", "The Breed" follows five young friends who vacation on a peaceful deserted island only to discover that the canines they befriend are genetically altered and possess a frighteningly high level of intelligence -- with an appetite to match.