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In a not so distant future, where overpopulation and famine have forced governments to undertake a drastic "One Child Policy," seven identical sisters live a hide-and-seek existence pursued by the Child Allocation Bureau. The Bureau, directed by the fierce Nicolette Cayman (Glenn Close), enforces a strict family-planning agenda that the sisters outwit by taking turns assuming the identity of one person: Karen Settman (Noomi Rapace). Taught by their grandfather (Willem Dafoe) who raised and named them - Monday, Tuesday, Wednesday, Thursday, Friday, Saturday and Sunday - each can go outside once a week as their common identity, but are only free to be themselves in the prison of their own apartment. That is until, one day, Monday does not come home...
J.D. Vance (Gabriel Basso), a former Marine from southern Ohio and current Yale Law student, is on the verge of landing his dream job when a family crisis forces him to return to the home he’s tried to forget. J.D. must navigate the complex dynamics of his Appalachian family, including his volatile relationship with his mother Bev (Amy Adams), who’s struggling with addiction. Fueled by memories of his grandmother Mamaw (Glenn Close), the resilient and whip-smart woman who raised him, J.D. comes to embrace his family’s indelible imprint on his own personal journey.