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Dr. John Brinkley, a charlatan, scams his way to fame using fake medicine, populism, and radio. Dr. Morris Fishbein, editor of the journal of the AMA, begins a quest to take him down as Brinkley becomes more famous.
During the 1970s, FBI agents Jim Wedick and Jack Brennan infiltrate the world of Phillip Kitzer Jr, a Minnesota swindler who masterminds dozens of multimillion-dollar schemes, such as selling worthless securities from bogus offshore enterprises. His international network of associates is known as The Fraternity.