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Malignant Man focuses on Alan Gates, a cancer patient with a terminal diagnosis who is resigned to his fate until he discovers that his tumor is actually a mysterious parasite. Granted a second lease on life and incredible, otherworldly powers, Alan must fight against an evil army buried beneath society’s skin, all the while unlocking the secrets of his forgotten past.
John Farley, author of a best-selling self-help book about letting go of the past, violates his own advice when he returns to his small hometown to receive the community's highest honor. While there, John learns, to his horror, that his widowed mother, Beverly, is engaged to be married to none other than Mr. Woodcock, the gym teacher whose sadistic exploits were the bane of John's youth. Abetted by his nerdy old pal, Nedderman, John plots to break-up the relationship. But their well-laid plans go awry.