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After escaping a secret corporate facility overrun by the undead, Alice finds herself roaming the streets in the heart of the ravaged and deserted Racoon City. She has been subjected to biogenetic experimentation by the vast Umbrella Corporation and becomes genetically altered, with super-human strengths, senses and dexterity. These skills, and many more, will be needed if anyone is to stay alive.
A scientific expedition is assembled by a powerful pharmaceutical company to search for a rare black orchid in the deep recesses of the jungles of Borneo. Their hope is that the orchid can be used to unlock the secrets of youth and immortality. What they soon discover is that the orchid is already being used by a denizen host of giant snakes to augment their strength, size and vitality—not to mention their appetites.