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On Halloween Eve, in a small-town movie theater, an all-night Draculathon draws throngs of moviegoers who suddenly find themselves locked inside the theater, which is slowly filling with vampires.
Julian and the few friends who managed to escape from Necropolis are all now in college and putting their Hybratech experiences behind them. But that doesn't last as accidentally Julian and Jenny discover a sinister chemical canister hidden away in a secret room. Trying to dissect this chemical, labeled as Trioxyin-5, they leave it with their friend Cody for analysis. Unfortunately, Cody quickly sees the potential to create a new party drug out of it and make himself some easy money. He lies to Julian and produces a huge batch of 'Z' that he sells across the college campus. As the drug becomes more and more popular and Halloween approaches, practically everyone in the college has taken a little 'Z'. As hundreds of innocent college students become brain hungry zombies, holiday costumes make it difficult to tell who is still alive and who is one of the living dead!