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After being released from prison, a man known as The Rambler (Dermot Mulroney) stumbles upon a strange mystery as he attempts a dangerous journey through treacherous back roads and small towns en route to reconnecting with his long lost brother.
Six college friends meet up for a carefree weekend that turns deadly. A terrorist attack in a nearby town infects much of the townspeople with a deadly virus that induces rabies-like symptoms, only far more severe. Several of those infected (the title characters) attack the estate where the friends have been vacationing. Can they survive? Where will they hide? Is anyone left? Will we ever get our fill of these flesh eating zombie fiends?