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"XX/XY" is a tale about a trio composed of a young artist, Coles, and two Sarah Lawrence undergrads, Sam and Thea, who, on the night they meet, tread briefly on the wild side of sexual lust and drunken experimentation. As friends and, at some points, alternately couples and/or lovers, the three carry on a relationship that ends dramatically. Quite by accident, the relationship is reborn a decade later, and passionate desires are significantly reopened.
College is finally over and five friends escape to a remote log cabin in the woods to enjoy some last days of decadence before entering the working world. Merriment and good times sour when a delirious stranger covered in bloody sores crashes their party. Shots are fired and the lunatic flees into the woods, but it's too late for our five friends: contact was already made. Soon one member of the circle gets ill and her skin starts to bubble and burn as a trail of oozing sores ravages her flesh. The group's compassion quickly turns to repulsion and terror as their friend deteriorates before their eyes.